Search Results - healthcare

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Integrated Dual-Modality Microfluidic Sensor for Biomarker Detection
Summary: ISU researchers have developed a process that relates to microfluidic sensing that uses biomarkers to detect cancerous features in humans.  The invention utilizes surface plasmon resonance (SPR) technology described in ISURF 4453 as well as electrochemical sensing to form a dual-modality sensor.  The electrochemical component allows for high...
Published: 7/24/2019
Category(s): Medical Devices, Sensors & Controls, Engineering & Physical Sciences, Healthcare
Anti-Alpha-Synuclein Monoclonal Antibodies for Diagnostics and Therapeutics
Summary: Iowa State University researchers have developed anti-alpha-synuclein antibodies that preferentially bind to aggregated alpha-synuclein. The antibodies can be used for an early screening test for alpha-synuclein associated diseases (such as Parkinsons' disease) with potential therapeutic uses to include the treatment of Parkinsons' disease...
Published: 5/10/2019
Category(s): Life Sciences, Healthcare
Codon optimized nls-Mad7-nls for targeted double-strand breaks in vertebrates
Summary: This disclosure relates to vectors carrying a modified MAD7 gene optimized for high expression in vertebrates, including  zebrafish and human cells. Description: Mad7 is a novel RNA-guided nuclease described by Inscripta with high potential for gene editing.  To our knowledge, there are no published reports of Mad7 nuclease activity in vertebrate...
Published: 5/2/2019
Category(s): Agriculture, Life Sciences, Healthcare, Veterinary Medicine
Influenza Nanovaccine
Summary: ISU researchers have developed an intranasally administered biocompatible polyanhydride nanoparticle-based influenza A virus (IAV) vaccine (IAV-nanovax) capable of providing robust protection against subsequent homologous and heterologous IAV infections.Description: IAV is a major cause of respiratory illness worldwide and typically responsible...
Published: 4/30/2019
Category(s): Life Sciences, Healthcare, Veterinary Medicine
Enhanced Isothermal Nucleic Acid Amplification Reaction Systems using Magnetic Ionic Liquids
Summary: Iowa State University researchers have developed a method for rapid detection of pathogens.Description: Isothermal nucleic acid amplification (INAA) is an alternative method to standard amplification methods, such as polymerase chain reaction (PCR), for the rapid detection of nucleic acids from pathogens. INAA is highly sensitive, has high...
Published: 4/11/2019
Category(s): Life Sciences, Healthcare, Engineering & Physical Sciences
Smart Contact Lens for Intraocular Pressure Monitoring, Drug Release and Disease Biomarker Detection
Summary: Our contributors demonstrated a new type of contact lens for an optical monitoring of intraocular pressure (IOP) in real-time, drug delivery and disease biomarker detection.Description: Glaucoma is a leading cause of irreversible blindness worldwide. Elevated Intraocular pressure (IOP) is the primary known risk factor for glaucoma nerve damage...
Published: 4/11/2019
Category(s): Healthcare, Medical Devices, Sensors & Controls, Veterinary Medicine
Synthesis, surface modification and self-assembly of Au-Fe3O4 nano-dumbbells
Summary: ISU researchers have developed an improved iron oxide-gold Janus nanoparticle with controllable lobe size ratios. Description: Principles of self-assembly control how molecules form into larger structures that are important for various aspects of biology.  Janus particles have different chemistries on two sides of a single particle, which...
Published: 3/6/2019
Category(s): Engineering & Physical Sciences, Healthcare, Research Tools & Design Tools
Isolation and Characterization of Porcine Sapelovirus Strain US/ISU26908B/18
Summary: This disclosure isolated a novel porcine sapelovirus (PSV) from a swine spinal cord sample. Description: Porcine Sapelovirus (PSV) is an emerging cause of atyptical neurological disease in swine resulting commonly in a herd mortality of 1-3%, and occasionally up to 10% on affected farms. Currently there is no purified cell-adapted PSV virus...
Published: 2/25/2019
Category(s): Healthcare, Life Sciences, Veterinary Medicine
Genetic Elements in Enterococcus spp. to Produce Dopamine
Summary: This disclosure provides a biotechnological approach to produce dopamine as well as a method to screen for probiotics. Description: In this disclosure, ISU researchers report the identification of a Enterococcus spp tyrosine decarboxylase gene and other genomic regions for the production of dopamine. Dopamine is a mammalian neurotransmitter...
Published: 1/28/2019
Category(s): Healthcare, Life Sciences, Veterinary Medicine
Quadruple Butterfly Coil (QBC)
Summary: Iowa State University researchers have developed a novel coil, namely Quadruple Butterfly Coil (QBC). This device has improved significant higher focality over the commercial Figure of Eight (FOE) coils with decreased stimulated area in brain. Model simulation results indicated that QBC stimulates a localized area of the brain, which minimized...
Published: 10/4/2017
Category(s): Engineering & Physical Sciences, Medical Devices, Healthcare, Life Sciences
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