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Genetic Basis and Test for Severe Combined Immune Deficiency in Pigs
Category(s):
For Information, Contact:
Dario Valenzuela
Senior Commercialization Manager, Life Sciences
515-294-4740
licensing@iastate.edu
Web Published:
12/7/2015
ISURF #
4044
Summary:
The genetic basis of Severe Combined Immune Deficiency (SCID) in pigs and tests that can be used to identify SCID pigs and SCID carriers have been established

Development Stage:
Description:
ISU researchers previously identified and documented, for the first time, the presence of SCID in pigs. Additional research on the experimental mutant pig line developed at ISU  enabled the identification of the genomic region harboring the causative mutation. The discovery  of the mutation allowed the development of genetic tests that can be used to identify SCID pigs and SCID carriers. The identification and understanding of the genetic basis for the SCID mutation will allow further characterization of the SCID phenotype for animal disease and biomedical research, including research into the immune system, cancer research, the effects of disease, cell and tissue transplantation, and for testing of new vaccines and therapeutic agents for immuno-compromised individuals. SCID pigs provide a much better animal model for such purposes than the widely used SCID mice and, thus, development of this model could potentially be extremely useful for advancing biomedical research and drug discovery . 

Group:
Advantage:
• Rapid ID of SCID pigs in litters for biomedical research
• Tool for  genetic surveillance of commercial pig lines

Application:
Biomedical research

Patent Information:
*To see the full version of the patent(s), follow the link below, then click on "Images" button.
Country Serial No. Patent No. Issued Date
United States 14/592,586 9,745,561* 8/29/2017


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