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Campylobacter jejuni peptide for vaccine development
Category(s):
For Information, Contact:
Dario Valenzuela
Senior Commercialization Manager, Life Sciences
515-294-4740
licensing@iastate.edu
Web Published:
1/31/2017
ISURF #
4559
Summary:
A promising target for designing a diagnostic test and peptide sequence for vaccine development to control Campylobacter jejuni infections in ruminants and humans.

Development Stage:
Description:
Campylobacter jejuni is a major causative agent for abortion in ruminants, particularly in sheep. It is also a major foodborne pathogen and a leading cause of enteritis in humans, responsible for 400-500 million cases of diarrhea annually worldwide each year. In the U.S. alone, C. jejuni accounts for more than 800,000 cases of foodborne illnesses each year. A hyper virulent clone of C. jejuni is the predominant cause of sheep abortion in the U.S. This disclosure identifies a peptide (AEEQGADLLGKSTISTTQKAAPFQADSLGNL) in the predicted external loop 4 of the major outer membrane protein of C. jejuni, which is essential for its hyper-virulence in inducing abortion. The loop 4 sequence is critical for virulence and provides a promising target for designing a diagnostic test and for vaccine development to control C. jejuni infections.

Advantage:
• Subunit vaccine
• Highly specific target
• No need to culture the pathogen

References:
Patent Information:
*To see the full version of the patent(s), follow the link below, then click on "Images" button.

Patent:
Patent(s) applied for

Direct Link: