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Metabolically Engineered Membrane Proteins for Improved Membrane Integrity and Production of Fatty Acids in Escherichia coli
Category(s):
For Information, Contact:
Craig Forney
Commercialization Manager, Chemistry and Materials Sciences
515-294-4740
licensing@iastate.edu
Web Published:
12/21/2016
ISURF #
4529
Summary:
ISU researchers developed a method of increasing the yield of high value fatty acids produced by E. coli

Development Stage:
Description:
Increasing productivity in the fermentative production of chemicals often hits a ceiling in product titer, either as a result of suppression in expression of enzymes necessary for the production pathway or in cell mortality due to high concentrations of the product itself. While removal of the product from the fermentation broth can address this “feedback” effect, an alternative and potentially less expensive solution to the problem is to modify the organism to be able to tolerate higher product concentrations. ISU researchers have used a combination of gene deletion and up-regulation to increase fatty acid titter by 53% compared to the non-engineered controls without negatively impacting cell viability.

Advantage:
• Greatly increased titter
• Inexpensive
• Uses existing fermentation systems

Application:
Fatty acid production from alternative sources
Patent Information:
*To see the full version of the patent(s), follow the link below, then click on "Images" button.

Patents:
Patent(s) Applied For


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