3876

There is a need to have highly pathogenic strains of Mycoplasma bovis to challenge cattle that are vaccinated with vaccine candidates against Mycoplasma bovis in order to test the efficacy of the vaccine candidates. ISURF is making available for licensing on a non-exclusive basis two Mycoplasma bovis strains (M23, 428E) suitable to help validate Mycoplasma bovis vaccine candidates and for diagnostics.  The strains were recovered from two different outbreaks of Mycoplasma bovis pneumonia and polyarthritis in Iowa cattle.  Description of one of the outbreaks has been published.  Description of the pathogenic potential of both strains has been presented at conferences.  One of the strains (M23) has been used as standard strain for cattle infection reports, and as wild-type to develop various mutants with gene disruptions or deletions.

• Well-characterized strains

• Suitable for diagnostics and vaccine validation

Research, Diagnostics, Vaccine Validation Studies

Rosenbusch, R. F. Bovine mycoplasmosis. Proceedings of the 34th Annual Convention of the American Association of Bovine Practitioners, pp 49-52, Vancouver, British Columbia, 2001.