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Iowa State University researchers have developed an implanted vaccine device designed to generate life-long antibody titers. The basis of the innovation is the slow release of an antigen embedded in a polymeric matrix. Antigen release is a function of the level of circulating antigen-specific antibodies.  By sensing the antibody levels, the device self-regulates antigen release thus ensuring antigen availability for continued antibody production.

The technology is a three-stage vaccine device, where stage 1 consists of vaccination with the antigen of interest using soluble adjuvant-based delivery. Stage two is a boost delivered using bio-erodible nanoparticles. Stage three is the “smart release” of vaccine where vaccine release is linked to antibody levels. The smart release utilizes a fibrillary matrix where, if immune complexes of antibody and antigen are present, they will be hindered from escaping the depot. If antibody levels fall, the complexes are dissociated and the antigen is small enough to escape from the vaccine depot. This provides a booster-like response leading to increased antibody production.

• Enables immune-regulated release of vaccine

• May reduce or eliminate the need for future booster vaccinations

• May be used with a number of various vaccines

• Addresses a very large market

Animal Health / Vaccine Development