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Non-Steroidal Anti-Inflammatory Plant Compounds for Nutraceutical or Pharmaceutical Uses
Category(s):
For Information, Contact:
Dario Valenzuela
Senior Commercialization Manager, Life Sciences
515-294-4740
licensing@iastate.edu
Web Published:
5/13/2015
ISURF #
3460
Summary:
Iowa State University researchers have identified compounds in orangegrass that have anti-inflammatory activity.

Development Stage:
Molecular structure has been identified, and anti-inflammatory activity with limited cytotoxicity has been demonstrated at concentrations as low as 2 micromolar using purified compounds in a bioassay with lipopolysaccharide-stimulated mammalian cells.  ISU is seeking partners interested in commercializing this technology.

Description:
Medicinal plants, such as St. John’s Wort, have received attention as supplements to treat various conditions or to promote general health and well-being.  These plants also represent a valuable resource for the identification of compounds that may have utility as new therapeutic agents.  Hypericum gentianoides, or orangegrass, is a plant native to the eastern half of the United States that was used by Native Americans to treat a variety of disorders, such as fever or wounds.  While investigating the properties of organgegrass, ISU researchers have identified a series of closely related compounds in its extracts that exhibit anti-inflammatory activity through inhibition of prostaglandin E synthesis.  These compounds are abundant in orangegrass relative to other secondary metabolites, demonstrate anti-inflammatory activity at low doses, and exhibit low cytotoxicity.  Thus, these natural compounds may have utility as nutraceuticals or as the basis for the design of novel therapeutic agents.

Advantage:
• Effective (doses as low as 1 ug/ml show anti-inflammatory activity)
• Abundant (the bioactive compounds account for approximately 20% of the dry plant tissue or 2% of the fresh tissue)
• Nontoxic (cytotoxicity is not observed at doses with anti-inflammatory activity)
• Versatile (may be used without modification for nutraceutical applications or as the starting point for new drug development)
Application:
Novel Anti-Inflammatory Agents for Topical Use or Drug Development

References:
Patent Information:
*To see the full version of the patent(s), follow the link below, then click on "Images" button.
Country Serial No. Patent No. Issued Date
United States 12/129,391 7,854,946* 12/21/2010


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