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Disease Resistant Rice
Category(s):
For Information, Contact:
Dario Valenzuela
Senior Commercialization Manager, Life Sciences
515-294-4740
licensing@iastate.edu
Web Published:
5/4/2015
ISURF #
3974
Summary:
Iowa State University researchers have developed disease resistant rice using genome editing technology.

Development Stage:
Description:
Bacterial blight is a major disease in rice—a crop that feeds half the world’s population. The TALEs (transcription activator-like effectors) proteins secreted by Xanthomonas bacteria  induce disease in susceptible rice plants  by binding to specific DNA sequences to activate gene expression. In rice, TALEs  secreted by X. oryzae pv. oryzae (Xoo) act as virulence factors and activate transcription of disease susceptibility, or S genes. One important bacterial blight susceptibility gene is Os11N3.To test the possibility of developing bacterial blight resistant plants, ISU researchers used the targeted genome editing capability of TALENs (TAL effectors fused to a DNA cleavage domain to generate specific nucleases) to edit the Os11N3 gene. The experiments were successful resulting in disease resistant mutant plants that were morphologically normal compared to wild-type plants, indicating that the known developmental function of Os11N3 was preserved.  This application demonstrates the utility of TALENs for making specific modifications in endogenous plant genes, and consequently may have broad applicability for streamlining plant breeding for the development of new agronomically important traits.

Advantage:
• Increased bacterial blight resistance without introducing foreign genes
• Rapid route to creating disease-resistant rice in elite lines
Application:
Crop improvement

References:
Patent Information:
*To see the full version of the patent(s), follow the link below, then click on "Images" button.
Country Serial No. Patent No. Issued Date
United States 14/362,529 9,688,997* 6/27/2017


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